![]() ![]() These symptoms depend on the amount of nerve damage and which nerves are affected. This disrupts signals between the brain and spinal cord. While its cause is unknown, the disease triggers the immune system to attack the protective coating on nerve fibers. MS is a disease that affects the brain and spinal cord, and can lead to deterioration and permanent damage of the nerves. "Our findings represent a cost savings as well as an automated alternative to the arsenal of tests used to diagnose multiple sclerosis." "Among the advantages of kappa measurement is that it's a much easier test to run in the laboratory," says Ruba Saadeh, a research fellow in neuroimmunology in Mayo Clinic's Department of Laboratory Medicine and Pathology, and the study's first author. Oligoclonal bands are proteins that indicate inflammation of the central nervous system. The authors conclude the test is a valid alternative to a commonly used test to detect oligoclonal bands in cerebrospinal fluid, according to findings published in Mayo Clinic Proceedings. The validated test measures kappa immunoglobulin free light chains in cerebrospinal fluid. ![]() There are two types of light chains: kappa and lambda. are affected by MS, according to the National Multiple Sclerosis Society.Īn antibody typically consists of two immunoglobulin heavy chains and two light chains. Mayo Clinic researchers have validated a new antibody test to diagnose multiple sclerosis (MS), a potentially disabling disease of the brain and spinal cord.
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